METATHESIS OF ALKENES HAVING FUNCTIONAL GROUPS

Synthesis of tetrasubstituted alkenes via metathesis.

Fully substituted olefin generation via metathesis is presented. Catalyst development, optimization of reaction conditions and substrate screening are included. In addition, asymmetric alkene metathesis, the cross metathesis reaction for this transformation and its application in natural products will be discussed.

Ruthenium(II)-Pyridylamine Complexes Having Functional Groups via Amide Linkages

Tandem Ring-Opening-Ring-Closing Metathesis for Functional Metathesis Catalysts.

Use of a tandem ring-opening-ring-closing metathesis (RORCM) strategy for the synthesis of functional metathesis catalysts is reported. Ring opening of 7-substituted norbornenes and subsequent ring-closing metathesis forming a thermodynamically stable 6-membered ring lead to a very efficient synthesis of new catalysts from commercially available Grubbs' catalysts. Hydroxy functionalized Grubbs'...

Metathesis: Formal and Functional Considerations

Regioselective Wacker oxidation of internal alkenes: rapid access to functionalized ketones facilitated by cross-metathesis.